What is it?
The TAP trial is an AWH investigator-initiated trial.
Pain after an operation is not just an undesired effect of having surgery but causes many adverse health issues. Post-operative pain that requires greater amounts of strong pain medication (typically narcotics such as morphine or oxycodone) results in more complications (such as slow recovery of the bowel function, nausea, vomiting, aspiration, and increased falls). Pain management, with the goal of minimising narcotics, is important, and regional anaesthesia has a pivotal role in this. Regional anaesthesia involves placing local anaesthetic in a specific location to reduce the pain signals from nerves supplying the affected area with minimal whole-body effects. In the case of abdominal surgery, a proven way to do this is the transversus abdominus plane (TAP) block. This has been well studied and put into practice with reliable results when done either by the anaesthetist (guided by ultrasound) or by the surgeon during the operation. Our aim in the study is to see if surgically (laparoscopic) placed TAP blocks reduce postoperative pain and complications in emergency laparoscopic surgery.
Who do I speak to?
Where do I find more information?
For more information, contact Kate Reid
Thunderstorm asthma is a recurring public health emergency in South-Eastern Australia which occurs in springtime. The major identified risk factors for thunderstorm asthma is hay fever and allergy to ryegrass pollen.
The goal of the CARISTA study is to identify the risk of springtime allergic and thunderstorm asthma in allergic adults living in South-Eastern Australia.
To do this the CARISTA Study will recruit 530 people who have hay fever and test them for allergy to ryegrass pollen and undertake simple breathing tests.
Importantly, the CARISTA Study asks participants to track their hay fever and asthma symptoms during the rye grass pollen season in south-eastern Australia (October to December) over 2 consecutive years using a secure electronic diary.
By tracking these symptoms, we aim to identify indicators (biomarkers) in the body that helps identify people at risk of worsening asthma and severe asthma during ryegrass pollen season.
This knowledge will contribute to developing targeted protective strategies and treatments to reduce the burden of springtime asthma in the community.
Phone Number: +6183444578, Email: jdouglass@unimelb.edu.au
Name: Rachel Tham, PhD
Phone Number: +61390356053, Email: CARISTA-Study@unimelb.edu.au
See the CARISTA trial website
The DETECT-PM study aims to determine the sensitivity and specificity of tumour DNA detection in peritoneal fluid collected at the time of surgery for non-metastatic locally advanced (cT4, N0-2, M0) or perforated colon cancer to predict for peritoneal recurrence.Who is it for?You may be eligible for this study if you are a male or female over the age of 18 and have histologically confirmed colon adenocarcinoma that is amenable to curative intent surgery.Study details:Blood samples will also be collected pre-surgery, 4-6 weeks post surgery, 12 months post surgery and at recurrence (if applicable) for circulating tumour DNA (ctDNA) analysis. Participants with non-metastatic resectable colon cancer who have a high risk of peritoneal recurrence, defined as those with perforation or clinical T4 disease will have peritoneal fluid collected at the time of surgery.It is hoped that findings from this study will provide opportunity for earlier intervention to prevent peritoneal recurrence through the detection of clinically occult peritoneal metastasis.
See the Detect-PM trial information on the ANZ clinical trial registry
AWH welcomes new studies from commercial sponsors and collaborative groups. The AWH Research Office has a Clinical trial Research Support Service, and uses SiteDocs to facilitate clinical trial document management. Standard Operating Procedures are available on request.